Prudential UK & Europe chief executive Jackie Hunt is leaving the organisation after two years in the position.
Hunt was appointed to the role in 2013 and succeeded Rob Devey, who left to join advice firm Towry. She was previously finance director at Standard Life.
Prudential group investment director John Foley will become UK chief executive on an interim basis until a permanent successor is appointed.
Prudential group chief executive Mike Wells, who took over in June, says: “I would like to thank Jackie for the contribution she has made during a period of radical change in the UK marketplace.
“She leaves our UK life business in a strong position to continue to meet our customers’ long-term savings and retirement needs while delivering valuable returns for our shareholders. I am also delighted that we have someone with the experience and expertise of John Foley to take the business forward until a permanent successor is appointed.”