Dresdner Bank chief executive Bernhard Walter announced his resignation effective the end of April in the wake of the collapse of the merger with Deutschebank.
The merger will not go ahead easing fears that both German giants' UK fund management operations might have merged as a result.
The merger fell apart earlier this week, after Walter voiced concerns over the integration of Dresdner's city investment branch.
In his resignation speech, Walter made clear he blamed the other side, but still felt the needed to accept political responsibility for the failure.
Bernd Fahrholz, 52 will replace him.