The audit, accounting and business services firm says the job cuts have been made in order to reshape the business in the current market environment and remain competitive.
It says it has been a difficult decision and not one it has made lightly.
BDO Stoy Hayward operates across the UK with over 3,000 partners and staff.
Managing Partner Simon Michaels says: “The actions we have taken ensure we remain competitive. Our clients come first and our key priority is to focus our business and services around their needs, not only now but in the future.
“All the partners are well respected and have made a valuable contribution to the firm during their time as partners. We wish all the partners who are leaving the firm the very best for the future.”